Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses
نویسندگان
چکیده
منابع مشابه
Activation of the innate immune response by endogenous retroviruses.
The human genome comprises 8 % endogenous retroviruses (ERVs), the majority of which are defective due to deleterious mutations. Nonetheless, transcripts of ERVs are found in most tissues, and these transcripts could either be reverse transcribed to generate ssDNA or expressed to generate proteins. Thus, the expression of ERVs could produce nucleic acids or proteins with viral signatures, much ...
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Endogenous retroviruses (ERVs) are abundant in mammalian genomes and contain sequences modulating transcription. The impact of ERV propagation on the evolution of gene regulation remains poorly understood. We found that ERVs have shaped the evolution of a transcriptional network underlying the interferon (IFN) response, a major branch of innate immunity, and that lineage-specific ERVs have disp...
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15. S. D. Boyd et al., J. Immunol. 184, 6986–6992 (2010). 16. K. J. Jackson et al., Immunogenetics 64, 3–14 (2012). 17. A. Sanchez, S. G. Trappier, B. W. Mahy, C. J. Peters, S. T. Nichol, Proc. Natl. Acad. Sci. U.S.A. 93, 3602–3607 (1996). 18. S. K. Gire et al., Science 345, 1369–1372 (2014). 19. G. S. Mohan, W. Li, L. Ye, R. W. Compans, C. Yang, PLOS Pathog. 8, e1003065 (2012). 20. D. R. Bowle...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2018
ISSN: 1078-8956,1546-170X
DOI: 10.1038/s41591-018-0116-5